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Biomedical Engineering and Bioengineering Commons

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Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling 2020 University of Arkansas, Fayetteville

Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling

Biomedical Engineering Undergraduate Honors Theses

The ninth leading cause of death in the United States is kidney disease, and hemodialysis is the process most commonly prescribed for treatment. It utilizes a selectively permeable membrane filter to remove toxins such as urea from the blood and retain necessary protein levels. However, traditional filters, such as cellulose triacetate, used during dialysis can be inefficient in terms of separation performance and reduction of fouling. Recent exploration of nanoparticles has resulted in the creation of Oxone Mediated TEMPO-Oxidized Nano Cellulose which has properties that are believed to increase hydrophilicity, increase tensile capacity, decrease membrane resistance and lower fouling, making ...


Determination Of Gas Emission Characteristics From Animal Wastes Using A Multiplexed Portable Ftir-Surface Chamber System, Pakorn Sutitarnnontr 2020 Utah State University

Determination Of Gas Emission Characteristics From Animal Wastes Using A Multiplexed Portable Ftir-Surface Chamber System, Pakorn Sutitarnnontr

All Graduate Theses and Dissertations

Livestock production is a growing source of air pollution at regional, national, and global scales. Improved livestock manure management has the potential to reduce environmental impacts; however, there is an urgent need for cost-efficient, reliable, and easy to maintain measurement and monitoring capabilities to precisely quantify emissions from livestock manure. This research describes and evaluates a novel measurement method based on the multiplexed portable Fourier Transform Infrared (FTIR) spectroscopy analyzer - surface chamber techniques for continuous measurements and monitoring gas emissions from manure sources. The multiplexing system was designed and developed to automate the chamber network, controlling the movement of chambers ...


Effects Of Novel Tool Use: Cortical And Functional Measures In Children Using A Prosthetic Simulator, Chris Copeland 2020 University of Nebraska at Omaha

Effects Of Novel Tool Use: Cortical And Functional Measures In Children Using A Prosthetic Simulator, Chris Copeland

Student Research and Creative Activity Fair

As of 2005, there were a total of 1.6 million people living with the loss of a limb, with this population projected to double to 3.6 million by 2050 [1]. While prostheses aim to enhance the function of these individuals, it is estimated that 45% of pediatric prosthetic users reject their prosthesis [2]. The literature which describes the neurological control mechanisms of prosthetic use is sparse and often low-powered due to an inadequate number of participants. However, prosthetic simulators may be a solution to chronically low-powered prosthetic-centric studies by serving as functional homologues, though this has yet to ...


Autocorrelation And Probability Distributions In Gait-Metronome Synchronization, Charles Sloan 2020 University of Nebraska at Omaha

Autocorrelation And Probability Distributions In Gait-Metronome Synchronization, Charles Sloan

Student Research and Creative Activity Fair

Recent research has shown that the structure of different pacing signals influences gait dynamics during coordination to those signals. Those studies, however, have not looked at the impact that probability distribution functions play in influencing our gait. This study looks at how both autocorrelation functions and probability distribution has in noisy metronomes to look for sources of synchronization. 10 healthy subjects volunteered to complete this study. The participants were required to wear custom-built glasses with a small screen projected on the lens. The screen showed a visual stimulus that correlated with various signals. The results of the study suggest that ...


Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso 2020 California Polytechnic State University, San Luis Obispo

Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso

Biomedical Engineering

The purpose of this scope of work is to highlight the progress and development of SoloStand sponsored by Derek Herrera, chief technical officer and founder of SpinalSingularity. SoloStand is an attachment to a wheelchair that will benefit paraplegics that use wheelchairs. A portable and customizable attachment to a wheelchair will allow the user to do everyday tasks without transferring into a separate standing wheelchair and travel more easily. This document outlines everything that has been done in fulfillment of our senior project requirements.


Prosthetic Thumb, Allison M. Sigdestad, Sahil Sharma, Cale Foreman 2020 California Polytechnic State University, San Luis Obispo

Prosthetic Thumb, Allison M. Sigdestad, Sahil Sharma, Cale Foreman

Biomedical Engineering

The Prosthetic Thumb Project is a senior design project completed by Biomedical Engineering Undergraduate students at California Polytechnic State University. This senior design project is aimed at designing a prosthetic thumb for a Cal Poly Pomona student who lost their thumb in an accident last year. The patient has ultimately lost between 30-40% of functionality of his left hand, and so we would like to give him that mobility back. Originally, the patient was worried about having a prosthesis, and wanted something more stagnant that would resemble the look of the thumb he lost. However, after working with him, we ...


Pulmonary Imaging Of Chronic Obstructive Pulmonary Disease Using Multi-Parametric Response Maps, Jonathan MacNeil 2020 The University of Western Ontario

Pulmonary Imaging Of Chronic Obstructive Pulmonary Disease Using Multi-Parametric Response Maps, Jonathan Macneil

Electronic Thesis and Dissertation Repository

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction caused by airway remodelling and parenchymal destruction. Clinically, observation of COPD is performed using spirometry, but this technique only provides a global measure of lung health. To supplement these clinical measurements, thoracic computed tomography (CT) and hyperpolarized gas magnetic resonance imaging (MRI) have been used to measure regional structure and function abnormalities. Although CT and MRI have been used to research COPD, combination of both modalities into an interrelated image has never been performed. Therefore, we developed an image processing pipeline to combine MRI-CT information into a multi-parametric response ...


Sustainable, Alginate-Based Sensor For Detection Of Escherichia Coli In Human Breast Milk, Nicholas Kikuchi, Margaret May, Matthew Zweber, Jerard Madamba, Craig M. Stephens, Unyoung Kim, Maryam Mobed-Miremadi 2020 Santa Clara University

Sustainable, Alginate-Based Sensor For Detection Of Escherichia Coli In Human Breast Milk, Nicholas Kikuchi, Margaret May, Matthew Zweber, Jerard Madamba, Craig M. Stephens, Unyoung Kim, Maryam Mobed-Miremadi

Bioengineering

There are no existing affordable diagnostics for sensitive, rapid, and on-site detection of pathogens in milk. To this end, an on-site colorimetric-based sustainable assay has been developed and optimized using an L16 (54) Taguchi design to obtain results in hours without PCR amplification. To determine the level of Escherichia coli (E. coli) contamination, after induction with 150 μL of breast milk, the B-Per bacterial protein extraction kit was added to a solution containing an alginate-based microcapsule assay. Within this 3 mm spherical novel sensor design, X-Gal (5-Bromo-4-Chloro-3-Indolyl β-D-Galactopyranoside) was entrapped at a concentration of 2 mg ...


Target Flow-Pressure Operating Range For Designing A Failing Fontan Cavopulmonary Support Device, Masoud Farahmand, Minoo N. Kavarana, Phillip M. Trusty, Ethan Kung 2020 Clemson University

Target Flow-Pressure Operating Range For Designing A Failing Fontan Cavopulmonary Support Device, Masoud Farahmand, Minoo N. Kavarana, Phillip M. Trusty, Ethan Kung

Publications

Fontan operation as the current standard of care for the palliation of single ventricle defects results in significant late complications. Using a mechanical circulatory device for the right circulation to serve the function of the missing subpulmonary ventricle could potentially stabilize the failing Fontan circulation. This study aims to elucidate the hydraulic operating regions that should be targeted for designing cavopulmonary blood pumps. By integrating numerical analysis and available clinical information, the interaction of the cavopulmonary support via the IVC and full assist configurations with a wide range of simulated adult failing scenarios was investigated; with IVC and full assist ...


Paid Summer Research Opportunities With The Louisiana Biomedical Research Network, John L. Quebedeaux Jr., Gabrielle Broussard 2020 Louisiana Tech University

Paid Summer Research Opportunities With The Louisiana Biomedical Research Network, John L. Quebedeaux Jr., Gabrielle Broussard

Science Seminars

The Louisiana Biomedical Research Network Summer Research Program provides undergraduate and graduate students $4000 to $6000 in support, including housing if needed, for summer research with LBRN investigators located at various institutions across the state. This presentation will summarize the program and the application process. Additional details can be found at: https://lbrn.lsu.edu/summer-research-program.html


Low-Cost Solid State Nanopore Biosensing Technology Towards Early Disease Detection, Julian Bello 2020 Rowan University

Low-Cost Solid State Nanopore Biosensing Technology Towards Early Disease Detection, Julian Bello

Theses and Dissertations

Solid-state nanopore based biosensors are cost effective, high-throughput engines for single molecule detection of biomolecules, which is useful for detecting epigenetic modifications on DNA; one of these being the potentially cancerous hypo, or hypermethylation of CpG islands. Despite its immense potential in the realm of disease diagnostics, nanopore detection as it stands faces various limitations that inhibit it from widespread commercial use. These include the complex method of solid-state nanopore fabrication, fast DNA translocations through the pore causing poor resolution, and poor signal to noise ratio. The following work aims to improve the efficacy of the solid-state nanopore biosensing platform ...


Barn-Raising On The Digital Frontier: The L.A.U.N.C.H. Collaborative, Bradford W. Hesse, David Ahern, Michele Ellison, Eliah Aronoff-Spencer, Robin C. Vanderpool, Karen Onyeije, Michael C. Gibbons, Timothy W. Mullett, Ming-Yuan Chih, Victoria Attencio, Grant Patterson, Jessica Boten, Christopher Hartshorn, Ben Bartolome, Katie Gorscak, Melanie McComsey, Alexandra Hubenko, Bin Huang, Corey Baker, Don Norman 2020 National Cancer Institute

Barn-Raising On The Digital Frontier: The L.A.U.N.C.H. Collaborative, Bradford W. Hesse, David Ahern, Michele Ellison, Eliah Aronoff-Spencer, Robin C. Vanderpool, Karen Onyeije, Michael C. Gibbons, Timothy W. Mullett, Ming-Yuan Chih, Victoria Attencio, Grant Patterson, Jessica Boten, Christopher Hartshorn, Ben Bartolome, Katie Gorscak, Melanie Mccomsey, Alexandra Hubenko, Bin Huang, Corey Baker, Don Norman

Journal of Appalachian Health

A meta-analysis of oncology papers from around the world revealed that cancer patients who lived more than 50 miles away from hospital centers routinely presented with more advanced stages of disease at diagnosis, exhibited lower adherence to prescribed treatments, presented with poorer diagnoses, and reported a lower quality of life than patients who lived nearer to care facilities. Connected health approaches—or the use of broadband and telecommunications technologies to evaluate, diagnose, and monitor patients beyond the clinic—are becoming an indispensable tool in medicine to overcome the obstacle of distance.


Manufacturing Of Poly(Ethylene Glycol Diacrylate)-Based Hollow Microvessels Using Microfluidics, Saurabh S. Aykar, David E. Reynolds, Marilyn C. McNamara, Nicole N. Hashemi 2020 Iowa State University

Manufacturing Of Poly(Ethylene Glycol Diacrylate)-Based Hollow Microvessels Using Microfluidics, Saurabh S. Aykar, David E. Reynolds, Marilyn C. Mcnamara, Nicole N. Hashemi

Mechanical Engineering Publications

The microvasculature is a vital organ that distributes nutrients within tissues, and collects waste products from them, and which defines the environmental conditions in both normal and disease situations. Here, a microfluidic chip was developed for the fabrication of poly(ethylene glycol diacrylate) (PEGDA)-based hollow self-standing microvessels having inner dimensions ranging from 15 μm to 73 μm and displaying biocompatibility/cytocompatibility. Macromer solutions were hydrodynamically focused into a single microchannel to form a concentric flow regime, and were subsequently solidified through photopolymerization. This approach uniquely allowed the fabrication of hollow microvessels having a defined structure and integrity suitable for ...


Using An Internal Auditory Stimulus To Activate The Developing Primary Auditory Cortex: A Fetal Fmri Study, Estee Goldberg 2020 The University of Western Ontario

Using An Internal Auditory Stimulus To Activate The Developing Primary Auditory Cortex: A Fetal Fmri Study, Estee Goldberg

Electronic Thesis and Dissertation Repository

Insight into the rapidly developing brain in utero is scarce. Fetal functional magnetic resonance imaging (fMRI) is a technique used to gain awareness into the developmental process. Previous auditory task-based fMRI studies employed an external sound stimulus directly on the maternal abdomen. However, there has since been recommendation to cease doing so. We sought to investigate a reliable paradigm to study the development of fetal brain networks and postulate that by using an internal stimulus, such as the mother singing, it would result in activation of the fetal primary auditory cortex. Volunteers carrying singleton fetuses with a gestational age of ...


"When The Enemy Drew Our Attention": Reconsidering Prior Restraint In The Context Of Dual Use Research Of Concern, Caine Caverly 2020 William & Mary Law School

"When The Enemy Drew Our Attention": Reconsidering Prior Restraint In The Context Of Dual Use Research Of Concern, Caine Caverly

William & Mary Bill of Rights Journal

Through 2016 and 2017, a team led by Canadian virologist David Evans, and funded by an American pharmaceutical company, attempted to synthesize the previously extinct horsepox virus. After just six months and an expenditure of $100,000, the research team was able to successfully construct the virus “using only commercially available information, technology and tools.” In January of 2018, the team went on to publish their information in an American-based journal, PLOS ONE.

The publication was controversial because it included a potential “blueprint” for the synthesis of a genetic strand in the same viral family as the highly lethal, albeit ...


In Vitro Evaluation Of The Influence Of Substrate Mechanics On Matrix-Assisted Human Chondrocyte Transplantation, Yueh-Hsun Kevin Yang, Courtney R. Ogando, Gilda A. Barabino 2020 CUNY City College

In Vitro Evaluation Of The Influence Of Substrate Mechanics On Matrix-Assisted Human Chondrocyte Transplantation, Yueh-Hsun Kevin Yang, Courtney R. Ogando, Gilda A. Barabino

Publications and Research

Matrix-assisted chondrocyte transplantation (MACT) is of great interest for the treatment of patients with cartilage lesions. However, the roles of the matrix properties in modulating cartilage tissue integration during MACT recovery have not been fully understood. The objective of this study was to uncover the effects of substrate mechanics on the integration of implanted chondrocyte-laden hydrogels with native cartilage tissues. To this end, agarose hydrogels with Young’s moduli ranging from 0.49 kPa (0.5%, w/v) to 23.08 kPa (10%) were prepared and incorporated into an in vitro human cartilage explant model. The hydrogel-cartilage composites were cultivated ...


Fabrication Of Vascularized Scaffolds For The Treatment Of Spinal Cord Injury, Paul P. Partyka 2020 Rowan University

Fabrication Of Vascularized Scaffolds For The Treatment Of Spinal Cord Injury, Paul P. Partyka

Theses and Dissertations

The overall goal of the research presented here is to evaluate the efficacy of transplanting scaffolds containing central nervous system vasculature to repair spinal cord injury. There are three major phases of this effort: development of a three-dimensional model of central nervous system vasculature, transplantation of a pre-vascularized scaffold and optimization of the biomaterial used to deliver vasculature to the injured spinal cord. This research has produced the first ever compliant, three-dimensional (3D) blood-brain barrier (BBB) vessel. In order to create vascularized scaffolds appropriate for transplantation into a rat model of spinal cord injury, techniques to fabricate and spatially pattern ...


Heart Valve Isogeometric Sequentially-Coupled Fsi Analysis With The Space–Time Topology Change Method, Takuya Terahara, Kenji Takizawa, Tayfun E. Tezduyar, Yuri Bazilevs, Ming-Chen Hsu 2020 Waseda University

Heart Valve Isogeometric Sequentially-Coupled Fsi Analysis With The Space–Time Topology Change Method, Takuya Terahara, Kenji Takizawa, Tayfun E. Tezduyar, Yuri Bazilevs, Ming-Chen Hsu

Mechanical Engineering Publications

Heart valve fluid–structure interaction (FSI) analysis is one of the computationally challenging cases in cardiovascular fluid mechanics. The challenges include unsteady flow through a complex geometry, solid surfaces with large motion, and contact between the valve leaflets. We introduce here an isogeometric sequentially-coupled FSI (SCFSI) method that can address the challenges with an outcome of high-fidelity flow solutions. The SCFSI analysis enables dealing with the fluid and structure parts individually at different steps of the solutions sequence, and also enables using different methods or different mesh resolution levels at different steps. In the isogeometric SCFSI analysis here, the first ...


Bioadhesive Hydrogel Composite Cell Carrier For The Repair Of The Degenerated Intervertebral Disc, Thomas Richard Christiani 2020 Rowan University

Bioadhesive Hydrogel Composite Cell Carrier For The Repair Of The Degenerated Intervertebral Disc, Thomas Richard Christiani

Theses and Dissertations

Lower back pain (LBP) affects the worldwide population and can be attributed to the degeneration of the intervertebral disc (IVD). The IVD is composed of a central nucleus pulposus (NP), a peripheral annulus fibrosus (AF), and adjacent cartilage endplates (CEPs). IVD degeneration is characterized by proteoglycan loss, tissue dehydration, and decreased hydrostatic pressure. In this work, the use of an injectable bioadhesive hydrogel composite for replacement of the degenerated NP was investigated.

Results indicate that the composite exhibits similar mechanical properties to the NP, adheres to AF tissue, and supports encapsulated mesenchymal stem cell (MSC) differentiation toward an NP-like phenotype ...


Engineered Three-Dimensional Scaffolds Modulating Fate Of Breast Cancer Cells Using Stiffness And Morphology Related Cell Adhesion, Samerender Nagam Hanumantharao, Carolynn Que, Brennan Vogl, Smitha Rao 2020 Michigan Technological University

Engineered Three-Dimensional Scaffolds Modulating Fate Of Breast Cancer Cells Using Stiffness And Morphology Related Cell Adhesion, Samerender Nagam Hanumantharao, Carolynn Que, Brennan Vogl, Smitha Rao

Michigan Tech Publications

Goal: Artificially engineering the tumor microenvironment in vitro as a vital tool for understanding the mechanism of tumor progression. In this study, we developed three-dimensional cell scaffold systems with different topographical features and mechanical properties but similar surface chemistry. The cell behavior was modulated by the topography and mechanical properties of the scaffold. Adenocarcinoma (MCF7), triple-negative (MDA-MB-231) and premalignant (MCF10AneoT) breast cancer cells were seeded on the scaffold systems. The cell viability, cell-cell interaction and cell-matrix interactions were analyzed. The preferential growth and alignment of specific population of cells were demonstrated. Among the different scaffolds, triple-negative breast cancer cells preferred ...


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